Abstract:

The talk will cover our ongoing research into the lag phase that occurs when yeast cells are switched between glucose and other, less-preferred carbon sources. Our results show that the main bottleneck during the lag phase is the activation of respiration. Interestingly, the lag duration differs enormously between different yeast strains. A QTL analysis uncovered natural variation in an as-yet uncharacterized gene, YLR108C as the main determinant of natural variation in lag duration. YLR108C represses respiration in the presence of glucose, and certain alleles of the gene seemingly cause stronger Crabtree repression and thus evoke a longer lag phase, while allowing faster growth in high glucose conditions. As such, YLR108C is a rare (unique?) example of a gene that balances fitness optimization in variable vs stable conditions.

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