Session 35: Proteome efficiency of cellular energy production

04.04.2024 17:30

We want to discuss recent findings concerning the concept of proteome efficiency of cellular (energy) production. In particular, we would like to discuss the different definitions of protein efficiency and how to quantify it experimentally and theoretically. To this end, we will have brief presentations from several groups on their recent results. Topics of particular interest is the use of (presumably) low yield pathways by microorganisms, overflow metabolism, and the accounting of ATP. Everybody is invited to join the discussion!

With contributions from: Matteo Mori (UCSD), Pranas Grigaitis/Bas Teusink (VU Amsterdam), and Yihui Shen (University of Pennsylvania)

Selected Refs:

  • Shen et al. (2024): Mitochondrial ATP generation is more proteome efficient than glycolysis. Nat Chem Biol.
  • Mori et al. (2023): Functional decomposition of metabolism allows a system-level quantification of fluxes and protein allocation towards specific metabolic functions. Nat Commun 14.
  • Grigaitis and Teusink (2022): An excess of glycolytic enzymes under glucose-limited conditions may enable Saccharomyces cerevisiae to adapt to nutrient availability. FEBS Lett.

When: Apr 4, 2024 05:30 PM (CEST) Amsterdam, Berlin, Rome, Stockholm, Vienna

Register in advance for this meeting: https://univienna.zoom.us/meeting/register/u5wrduCoqD0oGtAWUvbmlT06qxbVbi3OIxLL

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